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For instance, a recent study focusing on a major worldwide military pollutant, namely the 2,4,6-trinitrotoluene (TNT), highlighted the role played by GSTUs in detoxifying this harmful and highly persistent pollutant by catalyzing its GSH-conjugation ( AtGSTU24 and AtGSTU25 , two genes whose expression is induced by TNT, was sufficient to enhance the ability of A

Furthermore, it conjugates with toxins in the liver via Glutathione S-transferase (GST) , facilitating their excretion [4]

Normally inhibited by IB, NF-B becomes activated upon 4-HNE-mediated phosphorylation and the degradation of IB, leading to the increased expression of pro-inflammatory cytokines [40,46]

doi: 10.1210/JC.2017-00970 9 TangSTangHSuHWangYZhouQZhangQet al
