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5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme that methylates nicotinamide using S-adenosyl methionine (SAM)

Potential for resistance or adaptation Whether the body adapts to NNMT inhibition over time is unknown

Results vary substantially based on the state of the follicles

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Treatment of diet-induced obese mice systemically with a potent NNMT inhibitor significantly reduced body weight and white adipose mass, decreased adipocyte size, and lowered plasma total cholesterol levels

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