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Inflammatory stimuli cause the release of cytokines such as interleukin (IL-1), IL-6, and tumor necrosis factor-a (tnf-a), which increase the synthesis and release of CRP [156]

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RhoA/ROCK pathway also mediates the contraction of CCSMCs by facilitating the phosphorylation of MLCP and induces the apoptosis of CCSMCs by activating the Akt/Bad/Bax/caspase-3 pathway

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