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Glucose homeostasis in HGKO mice In the postprandial state insulin acts in the liver via the PI3K/Akt2 pathway with the following effects: (1) repressed transcription of gluconeogenic genes, including Pck1 (encoding phosphoenolpyruvate carboxykinase [PEPCK]) and G6pc (encoding glucose 6-phosphatase [G6P]) and (2) increased transcription of Gck (encoding glucokinase [GCK]) and other genes that promote glycogen storage or glycolysis, to coordinately repress hepatic glucose production (HGP) and prevent postprandial hyperglycaemia [13]