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The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis

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This could be achieved via a tissue-targeted fusion protein approach with GLP-1-mediated delivery of E2 to tissues with high density of GLP-1Rsto minimize gynecological effectsthrough the use of fusion peptides (318, 319) or through novel SERMs that will retain the beneficial metabolic effects of E2 in desired tissues while antagonizing ERs in breast and uterus

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