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Against this profusion of negative findings in the rat, stand the results of studies conducted using optogenetic tools in mice, which implicate dopaminergic mechanisms in heroin self-administration [164, 165]
180:R37-R44 [PubMed: 30444723] 159

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Furthermore, although cigarette smoke exposure did not significantly reduce the number of oocytes, a thicker zona pellucida, and shorter and wider spindle bodies were observed (Jennings et al., 2011)

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Reagents for the assay were prepared fresh anoxically
