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38,39 In the MONICA/KORA study, the overall prevalence of neuropathic pain was 13.3% among diabetes patients, 8.7% in those with impaired glucose tolerance, 4.2% in those with impaired fasting glucose, and 1.2% in individuals with normal glucose tolerance

Here, voltage-gated Ca 2+ channels (VGCCs) were selected as molecular targets, as they play a significant role in synchronizing neuron excitability and transmission via synapses (99)

In addition to its tissue specific expression, right after dimerization with HIF-1, HIF-2 promotes the activation of different genes principally related to tumor growth, cell proliferation and cell pluripotency (39)

Biochem J 357:593615 Alexander JW, Supp DM (2014) Role of arginine and Omega-3 fatty acids in wound healing and Infection

Phytother Res 18(8):609614 Lu X, Deng T, Dong H, Han J, Yu Y, Xiang D, Nie G, Hu B (2022) Novel application of eupatilin for effectively attenuating cisplatin-induced auditory hair cell death via mitochondrial apoptosis pathway