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Knobil, E

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Diabetologia 68 , 16661673 (2025)

In adult animals, other causes of chronic external blood loss become more important (e.g., bleeding from tumors in the gastrointestinal tract, coagulopathies with bleeding from gastrointestinal or urinary tracts, etc.)

In line with this scenario, scavenging mitochondrial O 2 through MitoTEMPO blunted the activation of AKT, reverted the Warburg effect and induced death in melanoma cells

Comprehensive metabolic improvement is needed
