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10.1073/pnas.1401876111 PNAS 14 EsteyT.KangJ.SchwendemanS

Therefore, most specified interactions are with drug substrates of P-gp, such as dabigatran etexilate, sirolimus, digoxin, aliskiren, tenofovir alafenamide, etc., and would be affected by concurrent use with an inducer

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1 , 12 Precipitation Precipitation involves altering the solubility of proteins to cause them to aggregate and precipitate out of solution

In hepatocyte mitochondria, the reaction of NH 3 with ATP and the bicarbonate ion (HCO 3 ) leads to the formation of carbamoyl phosphate (CP) by CP synthetase (CPS), a key intermediate in the urea cycle

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