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The LCMS with positive and negative mode ionization with ESI were performed by inspecting a mass range of 100 to 1000 m/z at a scan rate of 4 spectra per second

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In vitro , IGF-1 has been shown to promote chondrocyte proliferation and lengthening of cultured metatarsals (Mushtaq et al., 2004) and to stimulate the production of matrix (Nixon et al., 2001)

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