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TBI not only results in neural injury, which is always followed by a number of complex and neuropsychiatric symptoms such as seizures, memory loss, insomnia, nervousness, and depression but also damages the brain and triggers cerebral edema, ischemia, and inflammation that disrupt homeostasis and induces unusual biochemical, metabolic, circadian, and neural circuit changes (Campos-Pires et al., 2020

2018;9 doi: 10.3389/fphar.2018.01162