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For instance, results from a study of a large number of chronic HF patients undergoing treatment show that increased TMAO content is positively correlated with the probability of death, worsening of patients condition, and probability of relapse in recovered patients within a short period of time (Organ et al., 2016) established a mouse HF model by surgery and found that mice fed TMAO showed more severe symptoms and signs of HF than mice fed a normal diet

As we age, natural collagen production declines, leading to signs of aging such as wrinkles and reduced skin elasticity

consider reducing the phenobarbital dose by 50%

In this process, TMAO activated the NLRP3 inflammasome and NF- signaling pathway ( in vitro study found that TMAO can also upregulate the NF-B signaling pathway to promote adipogenic differentiation and inhibit the osteogenic differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) ( Another study found that in the aorta of fish protein-fed mice, the atherosclerotic plaque area and degree of calcification were significantly higher than that of casein- or-soy protein-fed mice, but there were no significant changes in lipid-related content

Diabetes Obes Metab (2019) 21:127790