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Recent Progress in the Oral Delivery of Therapeutic Peptides and Proteins: Overview of Pharmaceutical Strategies to Overcome Absorption Hurdles

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265 Leu depletion in T cells leads to restricted mTORC1 signaling and inhibits T-cell activation

Both steps are necessary for the amelioration of psoriatic inflammation, although additional mechanisms have been proposed

Panels that pair flux readouts (e.g., DHE2-OH-E for O 2 , compartment-targeted HyPer/roGFP-Orp for H 2 O 2 , peroxiredoxin redox state) with damage footprints (F-isoprostanes, carbonyls/nitrotyrosine, 8-oxoG) and iron/ferroptosis metrics (labile iron pool, oxidized phospholipids, GPX4 context) provide the attribution needed to separate signalling from injury, compare studies and titrate therapy