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SCFAs, especially butyrate, modulate the immune system by activating G-protein-coupled receptors (GPCRs), particularly G-protein-coupled receptor 43 (GPR43) and G-protein-coupled receptor 109A (GPR109A) (169)

XO is the primary source of O2 in the GI tract

These usually improve within the first few weeks

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Recent research has indicated that patients with TED exhibited a significant increase in MHC II, B7, and PD-L1 expression on CD34 + fibrocytes