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Improve bone density fragility in Osteoporosis

PTP1B is a negative regulator of the leptin and insulin signaling pathways, so it has emerged as an attractive novel target for the treatment of both type 2 diabetes and obesity [51]

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Brebner K, Wong TP, Liu L, Liu Y, Campsall P, Gray S et al (2005)

Consequently, its rapid metabolism into active fragments and lack of systemic accumulation highlight a strong clearance profile, reducing the potential for peptide build-up or toxicity