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It was found that XH-14C reverse ABCB1-mediated MDR, enhancing the intracellular accumulation of the paclitaxelan ABCB1 substrate-drugby directly inhibiting the efflux function of ABCB1 without affecting the transporters expression and cellular localization [46]

Tumor-associated macrophages (TAMs) are found at high concentrations in the ascites of patients with OC due to the induction of monocyte differentiation into TAM by factors such as leukemia inhibitory factor and IL-6 (98)

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PMCID: PMC3654056

BPC-157 and TB-500 work through complementary pathways: BPC-157 through VEGF-driven angiogenesis and growth hormone receptor activation, TB-500 through actin regulation and cellular migration

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