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However, many studies suggest that microglial TNF potentially induces reactive astrogliosis through interactions with astrocytic TNFR, thereby modulating excitatory synapses and firing of PCs (Habbas et al., 2015

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Metformin improves cancer immunotherapy by directly rescuing tumor-infiltrating CD8 T lymphocytes from hypoxia-induced immunosuppression

Visual disturbances are reported most frequently [10]

Rarely, abnormal bone growth has been reported, but this is generally seen with high doses over extended periods for conditions other than acne

10.1016/j.chmed.2023.03.003 116 YangY.ZhongY.SuC.ZhangQ.YangM.ZhangX.et al (2022)