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doi: 10.1016/0090-6980(81)90123-4

doi: 10.3389/fphar.2024.1439536 Received 13 June 2024 Accepted 19 September 2024 Published 08 October 2024 Volume 15 - 2024 Edited by Karim Hosni, Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Tunisia Reviewed by Lourdes Franco, Faculty of Medicine.University of Extremadura, Spain Jolanta Orze-Gryglewska, University of Gdansk, Poland Updates Copyright 2024 Mu, Qu, Yin, Wang, Liu and Liu

Additionally, and as the cause of the variable HSCR phenotypes remains elusive, elucidating the contribution of the intestinal milieu for ENS development might indicate that next to genetic and epigenetic factors, environmental cues are also important to determine or attenuate HSCR pathology [56,57,58]

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Interestingly, this study also found that in cancer cell lines, telomere extension occurred through activation of the ALT (Alternative Lengthening of Telomeres) pathway rather than telomerase, suggesting cell-type-specific mechanisms