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Since NNMT is expressed in adipose, hepatic, and gut tissues 50,51,52 , and these tissues heavily cross-talk with the gut microbiome 53,54,55 , NNMTi treatment or its resulting weight loss effects 8,9 may modulate the microbiome

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Cyanocobalamin has been well researched and has proven to be very effective and well utilised in the body, in practice

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A safety review in the Journal of Obesity & Food Metabolism describes six randomized, double-blind, placebo-controlled trials evaluating AOD-9604, including oral dosing studies and longer phase II programs

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