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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Li Q, Chan H

Curcumin inhibits NF-kB activation inducing a down-regulation of specific inflammatory genes, with interesting therapeutic implications in MS (Srivastava et al., 1995

The response to linsitinib is inferior to the topoisomerase inhibitor topotecan, with median progression-free survival of 3.0 (95% CI 1.53.6) and 1.2 (95% CI 1.11.4) months for topotecan and linsitinib, respectively [159]

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Furthermore, autophagy is promoted by AMP activated protein kinase (AMPK), which is a key energy sensor and regulates cellular metabolism to maintain energy homeostasis

Acylcarnitines also affect epigenetic regulation in various ways
