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Synthesis, antiproliferative and anti-MDR activities of lathyrane diterpene derivatives based on configuration inversion strategy

In addition to above mentioned mechanism, GCs exert also non-genomic actions involving membrane-bound GRs [57]

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However, whereas neutralizing antibodies are constrained to recognizing limited epitopes involved in binding to and fusion with host cells, up to 95% of total spike-specific antibodies are non-neutralizing and can bind to epitopes spread across the spike protein 107,108

Our group recently described that a genetic disruption of the xCT subunit using CRISPR-Cas9 inhibits protein synthesis and proliferation in vitro ( 14 C-cystine transport assay in xCT knockout (xCT-KO) cells revealed this transporter as unique and indispensible for cystine uptake, as a complete abolishment of cystine transport has been observed