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Here, the authors 2 find elevated expression of ACTL6A in gastric cancer promotes glutathione synthesis by regulating 3 GCLC expression to suppress ferroptosis.
Glutathione production also declines with age and is lower in vegetarians and those with digestive concerns
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Compared to isogenic CFTR corrected cells (C38), the IB3-1 cells showed increased susceptibility to cell death upon exposure to iron in the form of ferric ammonium citrate (FAC) and the ferroptosis inducer, erastin
Glutathione is an antioxidant and, in its reduced form in the body, helps in fighting radicals
