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The effect of taking acetaminophen on sulfated sex hormones was roughly equivalent to the effect of 35 years of aging. [ref] This brings up a lot of concerns about acetaminophen and estrogen: its impact on pregnancy and implications for the fetus

& Hsu, S.-K

doi: 10.1530/EJE-12-0763 232 BhasinSBritoJPCunninghamGRHayesFJHodisHNMatsumotoAMet al

For many individuals, this becomes the maintenance dose, balancing substantial efficacy against manageable side effects

[5] That action has been primarily observed in the GI tract, but research has noted similar observations in muscle, neurological, and cardiovascular tissues

Nature 488 , 665669 (2012)