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Gene expression changes associated with sensitivity to DHA and DFO In parasites at 12 hpi, 3-h DFO treatment did not induce differential gene expression compared with the control group, whereas 3-h DHA treatment slightly altered functions related to ribosomes, pyridine metabolism, lysosomes, and purine metabolism

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Specifically, further investigations are needed to identify which patient groups benefit from physical chest clearance, mucus-modulating treatments, and regimens such as inhaled corticosteroids, long-acting beta-agonists, anticholinergics, and anti-inflammatory and antiinfective treatments