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She has had no recurrence during the 56 weeks since treatment

Tirzepatide is a dual GIP/GLP-1 receptor agonist while semaglutide acts only on GLP-1 receptors

A novel target for next-generation obesity medications is nicotinamide N-methyltransferase (NNMT) 7,8,9,10,11 , an enzyme central to cellular metabolism and energy homeostasis 12

For B12 supplementation experiments, we used the previously mentioned B12-deficient diet (Diet #1 in the text