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Huang et al., 2000)

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They can function as transcription regulators and microRNA sponges and have been linked to the progression of many human diseases, including cancer [204]

Chaperones attempt to remedy the unfolded protein first and, if unsuccessful, activate cellular programs, including the UPR, heat shock response (HSR), and ER-associated degradation (ERAD), to induce processes to either fix the problem or destroy the unfolded proteins (324, 325)