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Figure 1 Differential lipid metabolites Seven super classes with 30 differential lipid metabolites were observed between mild and severe patients, including PEs (8, 26.7%), TAGs (7, 23.3%), lysophosphatidylcholines (LPCs, 6, 20.0%), hexosylceramides (HCERs, 5, 16.7%), DAGs (2, 6.7%), FFAs (1, 3.3%), and CEs (1, 3.3%) ( Figure 2A

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2 Methods 2.1 Search strategy This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework

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