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J Asian Nat Prod Res (2009) 11:448

Research shows that SAM-e levels tend to be lower in depressed individuals compared to individuals who dont report signs of depression, so its believed that it does have beneficial effects when used for depression, but most of the trials that have been conducted only lasted a few weeks and included a small number of participants

That's the range DIY users should keep in mind when they want realistic cosmetic improvement rather than random experimentation

Executive function in Tourette's syndrome and obsessive-compulsive disorder

These favourable findings merit a balanced perspective

Testing this prediction, Field et al