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However, traditional drug nanosystems often face challenges such as potential toxicity, limited biocompatibility, and lack of multifunctionality, whereas natural products offer advantages like inherent biocompatibility and multi-targeting, making them a promising alternative for effective and safer CNS drug delivery

Common variants in Alzheimers disease and risk stratification by polygenic risk scores

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However, they induce open bleeding and, when penetrating into the mid-to-lower dermis (0.5-2 mm), can activate dense nociceptor networks, presenting an infection risk and user discomfort [63]

GSH-responsive drug delivery system for active therapy and reducing the side effects of bleomycin

This approach is integrated into a broader therapeutic framework in which specific probiotic strains, most notably Lactobacillus helveticus , Lactobacillus casei , and L