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06 Proteasome Activation (Clearing Protein Damage) : It activates the ubiquitin-proteasome system to remove misfolded and aggregated proteins, improving skin texture uniformity

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Over time, persistent follicular inflammation contributes to progressive miniaturization and, in its most severe expression, irreversible fibrosis of the follicular unit

J Clin Endocrinol Metab (1999) 84(10):3591601.10.1210/jcem.84.10.6037 214 HeinemeierKMMackeyALDoessingSHansenMBayerMLNielsenRHet alGH/IGF-I axis and matrix adaptation of the musculotendinous tissue to exercise in humans