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Recently, three more compounds ( 3d , 22e and 25 ) have been designed based on the C1-27 scaffold (Figure 12GI) [210]

In the liver, glutathione attaches itself to fat-soluble toxins, turning them into water-soluble compounds

Acknowledgments The authors acknowledge the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research at King Faisal University, Saudi Arabia (KFU251108)

229,230 Interestingly, in a patient with SCO2 mutations who presented with severe hypertrophic cardiomyopathy, Cu-histidine supplementation has been reported to improve heart function, showing attenuated cardiomyopathy as well as the normalization of blood pressure

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