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Relative AMPK121 activity on its substrate SAMStide, in the presence of vehicle (Veh), BSA, 100 M linoleic acid (LA), 10 M linoleoyl-CoA (LA-CoA), 10 M palmitoyl-CoA (PA-CoA) or 100 M AMP (n = 3 biological independent samples)

Additionally, direct dietary supplementation of TMAO increases atherosclerotic plaque formation in atherosclerotic susceptible mice suggesting a direct causal role of TMAO in the pathogenesis of atherosclerosis [2]

doi: 10.1002/ana.20473