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[63], after 4 weeks of MNA administration (100 mg/kg), no significant differences were found between MNA-treated and untreated diabetic db/db mice with regard to the levels of fasting blood glucose and HbA1c and the body weights of the MNA-treated db/db mice did not decrease but tended to increase compared to those of the untreated db/db mice

a recent safety analysis found no anaphylaxis in hundreds of patients receiving high-dose IV thiamine, suggesting the risk is very low in practice