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Simultaneously, other cells in the microenvironment undergo adaptive metabolic reprogramming in response [318]

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In response to invading microorganisms, phagocytic leukocytes release non-specific toxins, such as superoxide radicals, hypochlorous acid ("bleach"), and peroxynitrite
doi: 10.1186/s40842-015-0001-9

The restoration of normal oxygen level during reperfusion causes a release of cytokines and chemokines from activated tissue-resident macrophages and infiltration of pro-inflammatory neutrophils 26
