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Cancer 1993;71:745-50

A low serum/plasma zinc level is considered an important factor in the gut-liver axis to accelerate intestinal dysfunction, liver inflammation, hepatocyte damage and necrosis in the early stages of ALD
CSa and AH: figures

As an extension of the above, the brains high metabolic rate and oxygen consumption make it vulnerable to oxidative stress, which can lead to aging and neurodegenerative diseases like Alzheimers and Parkinsons Disease

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however, the specific criteria used to select donors were often inconsistent
