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Studies in rats showed an increased incidence of osteosarcoma with long-term PTH exposure, leading to an FDA boxed warning

Thaler, R., Spitzer, S., Karlic, H., Klaushofer, K

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Blaser, H., Dostert, C., Mak, T

doi: 10.1111/j.1365-2036.2008.03730.x
