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Arg, Ala, Glu and Tyr were selected as replacements to distinguish the relevance of the charge and size of the side chain and to mimic tyrosine-dependent glutathione transferases 3,18

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On the other hand, an elevated concentration of homocysteine, and its metabolites such as homocysteine thiolactone and N-homocysteinyllysine result in health problems and has been indicated as an independent risk factor for cardiovascular disease and accelerated atherosclerosis

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