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Barrera JG, Sandoval DA, DAlessio DA, et al

hPD-1scFv, humanized single-chain variable fragment against human PD-1

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Although the number of objectively improved patients in the mismatched group was higher than that in the matched group (2=4.374, P=0.036), the number of subjectively improved patients was significantly lower than that in the matched group (2=28.106, P=0.000)

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Some individuals experience mild gastrointestinal effects including nausea or abdominal discomfort, particularly with higher doses or when first initiating therapy