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One should keep in mind, however, that since the hydrodynamic radii of similarly shaped and chemically similar molecules are proportional to the molecular mass, one can consider SEC as a mass-based separation technique, even though this is not strictly true

The findings are remarkably consistent across studies

A number of studies report the development of white-matter lesions or retarded myelination in patients with B 12 deficiency

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2006;11(1) Adami LNG, Belardin LB, Lima BT, et al

Note : Always assess solvent compatibility during method validation to prevent adverse interactions with sensitive proteins