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Ferroptosis-inhibitory effect and possible mechanisms of ellagitannin geraniin

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Images obtained from the four rounds of staining were then registered, fused, and analyzed using HALO 3.1 image analysis software (Indica Labs)

In addition to mitigating IR-induced injury, melatonin inhibits ferroptosis in doxorubicin-induced cardiotoxicity, type 2 diabetic osteoporosis, and UVB-induced cataracts, among others [96,97,98]

For injured tissue that is poorly supplied with blood, this effect may be particularly relevant

According to the US Food and Drug Administration, Betnesol is a category C drug, which means animal studies have shown adverse effects on the unborn, and there are no well-controlled studies in humans (5)