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Time-dependent responses have also been observed in juvenile seabream, where significant MT induction occurred 12, 24, and 48 hours after exposure to CdCl 2 , indicating that the timing of sampling is crucial for accurately capturing MT expression patterns following heavy metal challenge ( znt1, znt5, and znt7 ), Zn-regulated iron-regulated transporter-like proteins ( zip8 and zip10 ), and MTs

The effect of Fer-1 was verified with experimentally administered ventricular Fer-1 in experiments with rats, where it was found to inhibit erastin-induced accumulation of ROS in the cytoplasm and lipids, resulting in a decrease in ROS and lower levels of ferroptosis, demonstrating that Fer-1 could appreciably slow down the onset of ferroptosis in the brain (171)

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Copper poisoning symptoms may present as abdominal pain, vomiting, chest pain, chills, cough, fever, general weakness, anemia, burning sensations, tremors, and a metallic taste in the mouth

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For example, certain anti-cancer therapies like radiotherapy and some chemotherapy drugs could produce oxidative stress in tumor cells by increasing ROS components and induce tumor cell death