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As was previously mentioned, levels of GH and IGF-1 steadily decrease over a lifespan, and with the lower hormone levels comes a myriad of side effects such as increased fat mass, cardiovascular dysfunction, decreased muscle mass, and declined cellular protein synthesis

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A total of 1 h after successful modeling, the mice in the RGSH group received an intraperitoneal injection of 800 mg/kg RGSH (13) and the mice in the other two groups were administered an equal volume of normal saline, this was repeated for 6 consecutive days

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"Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese." Journal of Clinical Endocrinology & Metabolism