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The foundational evidence is a 2017 Cell study in aged and progeroid mice , where FOXO4-DRI reduced senescent-cell burden and restored markers such as fur density and renal function [3]

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consistently no thrombocytopenia (amputation only) or attenuated thrombocytopenia in heparin- and warfarin-rats, along with lesser bleeding amounts than corresponding control-heparin- and control-warfarin-rats

However, the rate of senescent cell accumulation increases with age, resulting in pervasive damage and deficient cell clearance that disturbs tissue homeostasis