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Research indicates that interactions within the HGF system may initiate downstream signaling pathways, including kinase-mediated cellular responses and intracellular messenger activation

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Protracted upregulation of leptin and IGF1 is associated with activation of PI3K/Akt and JAK2 pathway in mouse intestine after ionizing radiation exposure

An open-label biomarker study of EMA401 was conducted in a phase II clinical trial of OIPN patients to prove the conceptual use of EMA401 in OIPN

Each domain is assessed using questions with an overall evaluation of low risk, some concerns, or high risk of bias

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