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doi: 10.1038/nrd.2015.21 110 WenPYKesariS
To enhance the accuracy and reliability of WHP assessment, future studies must develop and validate standardized assessment tools and methods (SATMs)
Ferroptosis is a RCD caused by intracellular iron accumulation combined with disruption of antioxidant systems, such as GPX4 inactivation and GSH depletion, and subsequent accumulation of toxic lipid peroxides (Dixon et al., 2012
116 Gaband-RodrguezE.KeaneL.CapassoM
In addition to being a therapeutic target, oxidative stress has been shown to decrease the GSH:GSSG ratio which has proven useful as a clinically accessible, pharmacodynamic biomarker of immune redox tone for conditions such as malignancy (Zitka et al., 2012)
(b) Effective date
