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Vitamin B-12 Vitamin B-12 plays an important role in the formation of red blood cells (RBCs) and aiding in neurological function

This "paradoxical response" (where treatment temporarily makes symptoms worse) includes: Numbness and tingling Shooting pains Joint pain Increased sensitivity Temporary inflammation (swelling and irritation) While these symptoms generally indicate that treatment is working (as nerves begin to repair themselves), they can be distressing for patients and may require additional treatment for comfort

(2000) The combination of insulin-like growth factor I and insulin-like growth factor-binding protein-3 reduces insulin requirements in insulin-dependent type 1 diabetes: evidence for in vivo biological activity

J Vet Pharmacol Therap 2014

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Thus, the intake of B12 through the diet should be significantly higher, since not all B12 from the diet can actually be absorbed