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Excess catecholamines can induce coronary artery constriction, raise heart rate, and increase myocardial oxygen consumption

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This nasal spray format is used in research settings as a delivery method that allows investigators to study peptide uptake and systemic distribution without gastrointestinal degradation

148 These findings raise the possibility that azathioprine may be an intrinsic (dose related) hepatotoxin in dogs, with possible adaptive tolerance to liver injury