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Patients tolerated UPT well during induction and maintenance therapies, and there were no new safety risks [180, 181]

The majority of cases of MN-pCT are linked to TP53 mutations, which are particularly detrimental when present as biallelic or "multi-hit" alterations, defined as the presence of two or more TP53 mutations or a single TP53 mutation accompanied by a 17p deletion or copy-neutral loss of heterozygosity (cnLOH) at the TP53 locus

The Future of Contested Spaces: As the battle space becomes increasingly crowded and noisy with more threats and more signal, traditional systems are struggling to keep pace

Results: Lactobacillus reuteri NCUF203.1 and Lactobacillus brevis NCUF207.7, of which fermentation supernatant had high inhibitory activity against XOD, were screened out and administered into HUA mice

doi: 10.1021/jasms.3c00201

Furthermore, Cys supplementation enhances intracellular levels of GSH, a major cellular antioxidant, which contributes to the suppression of pro-inflammatory cytokine production factors known to impair TJs integrity and increase epithelial permeability (Hasegawa et al