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Body weight is not the only determinant of exposure, but copying the trial ladder into a lighter, metabolically healthy population is not a neutral translation

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It has a well-established safety profile, and its toxicity is uncommon and dependent on the route of administration and high dosages

Most physicians recommend periodic treatment breaks (4-6 weeks off after 3-6 months of use) to assess ongoing need and prevent potential tolerance development

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For that reason, health care providers have used semaglutide for more than 15 years to treat Type 2 diabetes