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Mitochondrial nicotinamide adenine dinucleotide reduced (nadh) oxidation links the tricarboxylic acid (tca) cycle with methionine metabolism and nuclear DNA methylation

Persistent and uncontrolled oxidative stress and exacerbating NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) inflammasome activation during severe COVID-19 disease (Lage et al., 2022), induce production of pro-inflammatory cytokines, such as IL-1 and IL-18, that can be explained because of sharply decreased macrophage GSH intracellular levels associated with increased GSH efflux (Zhang T

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De Groot, A

Hosogi, S

In support of this, pharmacological inhibition of HDAC8 in breast cancer cells triggers both apoptosis and autophagy, indicating a switch from pro-survival to pro-death signaling upon HDAC8 blockade